New Device Developed for Nitric Oxide Sensing in Diabetic Foot Ulcers
Understanding Diabetic Foot Ulcers
Researchers in Michigan have introduced an innovative nitric oxide sensing device that sheds light on the underlying causes of diabetic foot ulcers and potential treatment options. Annually, an estimated 9 to 26 million individuals with diabetes globally develop foot ulcers, which can significantly increase the risk of mortality and may require up to 120 days for healing.
The Role of Nitric Oxide in Healing
Previous studies indicate that the impaired healing seen in diabetic foot ulcers is linked to unregulated nitric oxide levels. However, accurately measuring live concentrations of nitric oxide has been challenging due to its highly reactive nature. Traditionally, researchers have relied on nitrite, a stable byproduct, to infer nitric oxide levels indirectly.
Research Findings from Michigan Technological University
A collaborative team from Michigan Technological University and Central Michigan University has made strides in this area by developing a system for real-time measurement of nitric oxide concentrations. Their findings were published in the journal Medical Sciences.
To simulate diabetic and non-diabetic environments, the researchers exposed cells to both normal and elevated glucose conditions and measured nitric oxide production in each scenario. The results revealed that nitric oxide levels were significantly lower in high glucose conditions compared to normal glucose levels.
Correlation Between Nitric Oxide and Nitrite
Further analysis indicated a correlation between nitric oxide and nitrite levels under normal glucose conditions. However, this relationship did not hold under high glucose conditions, leading the researchers to conclude that nitrite concentrations are not reliable indicators of nitric oxide levels in diabetic wounds.
Future Plans for Commercialization
The research team is now focused on commercializing their real-time nitric oxide sensing device. They aim to develop a nitric oxide bandage that can deliver optimal concentrations of nitric oxide to affected areas, potentially reducing the healing time for diabetic foot ulcers significantly.
Reference
Kwesiga P, Cook E, Hannon J, Wayward S, Gwaltney C, Rao S, Frost C. Investigative Study on Nitric Oxide Production in Human Dermal Fibroblast Cells under Normal and High Glucose Conditions. Med Sci (Basel). 2018 Nov 9;6(4): pii: E99. doi: 10.3390/medsci6040099.